Founded in May 2005, the Center is mainly focused on model-based quantitative assessment of pharmacodynamics and pharmacokinetics. As one of the major institutions in pharmacometrics study, the Center is affiliated to the Professional Board of Pharmacometrics, Chinese Pharmacological Society.
Led by Director Prof. Zheng Qingshan and consultant Prof. Sun Rui-yuan, the Center has 12 staff members. We have developed extensive collaborative studies on quantitative research design, mathematical modeling and simulation.
Our staffs have published more than 100 academic paper and authored A New Perspective of Mathematical Pharmacology. At present, the Center has 4 Master degree students and 4 doctorate students.
Our research orientations
lModel-based quantitative assessment of pharmacodynamics
lStudy of pharmacokinetic drug interactions
lStudies of population pharmacokinetics, population pharmacodynamics and physiological pharmacodynamics
lLi GF, Yu G, Liu HX, Zheng QS. Ethnic-specific in vitro-in vivo extrapolation and physiologically based pharmacokinetic approaches to predict cytochrome P450-mediated pharmacokinetics in Chinese population: opportunities and challenges. Clinical Pharmacokinetics 2014; 53:197-202. (IF=6.1)
lWang K, D'Argenio DZ, Acosta EP, et al. Integrated population pharmacokinetic/viral dynamic modelling of lopinavir/ritonavir in HIV-1 treatment-naive patients. Clin Pharmacokinet, 2014. 53(4): 361-71. (IF2013=6.1)
lLi LJ, Li XX , Xu L, Sheng YC, Huang JH, Zheng QS. Systematic evaluation of dose accumulation studies in clinical pharmacokinetics. Current Drug Metabolism. 2013; 14: (5): 605-615. (IF=5.113)
Prof. Zheng Qingshan, male, MD, doctoral supervisor, is the director of the Center for the Study of Clinical Drug Trial. He is currently the director of Professional Board of Pharmacometrics, Chinese Pharmacological Society. He sits onthe editorial boards of the Acta Pharmacologica Sinica (English version), Acta Pharmacologica Sinica, Chinese Journal of New Drugs, Global Forum, the Chinese Journal of Clinical Pharmacology and Adverse Drug Reactions Journal. His research priority is pharmacometrics.
Wang Kun, PhD, associate senior researcher, a Master degree supervisor is an expert on mathematical modeling, simulation study and multilingual programming. He has conducted 2 years of pharmacometrics study in the United States. In addition, he has also been involved in the data analysis of collaborative research between China and overseas partners including Texas A&M University (USA), the Slovak Academy of Sciences (SAS) and RIKEN, Japan. His research focus is pharmacometrics.
Address: Room 820, Library Building, 1200 Cailun Road, Pudong New Area, Shanghai