Established between the SHUTCM and Prof. Ferid Murad, a Noble laureate in Physiology or Medicine, the Center seeks to facilitate its modernization and internationalization of Chinese medicine through innovative basic and applied research.
Our research interests
lExtraction and discovery of active components
lSignalling of inflammatory cells
lPreparation of Chinese materia medica
Our research projects
lBranch projects of National Basic Research Program of China (973 Program)
lNational Natural Science Foundation (General) Program
lNational Natural Science Foundation for Young Scholars
lProject of the State Administration of Traditional Chinese Medicine
lThe Rising-Star Program of Shanghai Science & Technology Commission
lSpecific Project for Modernization of Chinese Medicine
lSpecific Project of Nanotechnology
lInnovation Project of the Shanghai Education Commission
lThe third prize of Shanghai Science & Technology Progress (2014)
lInternational SHR Association—Young Researcher Award (2012)
lAuthored two books: Molecular Targets of Drugs: Convergence and Divergence and Cutting-Edge Technology in Life Science and TCM Study
Currently, the Center has 7 full-time researchers and 2 technicians.
Honorary Chairman: Prof. Ferid Murad
Director: Prof. Bian Ka
Deputy Director: Prof. Xu Jinwen
Bian Ka, Research focus: Anti-cancer and cardiovascular pharmacology
Xu Jinwen, Research focus: cardiovascular pharmacology from the molecular level and longevity medicine
Zhang Dandan, Research focus: Role of tumor-associated inflammation in breast cancer metastasis and discovery and mechanism in new Chinese medicine
Zhang Ting, Research focus: Active components in Chinese materia medica and quality evaluation
Liu Jun, Research focus: Action mechanism of Chinese medicine for cancer and tumor stem cells
Hu Kaili, Research focus: Construction of new delivery system of Chinese medicine and targeting preparation
Li Yajuan, Research focus: Cardiovascular pharmacology, inflammation medicine and Chinese medicine for diabetes
Ling Shuang, Research focus: Cardio-cerebrovascular pharmacology and longevity pharmacology
1.Zhu T, Zhang L, Ling S, Duan J, Qian F, Li Y, Xu JW. Scropolioside B inhibits IL-1ß and cytokines expression through NFκB and inflammasome NLRP3 pathways. Mediators of Inflammation. Accepted 20 August 2014.
2.Zhang L, Zhu T, Qian F, Xu JW, Dorje G, Zhao Z, Guo F, Li Y. Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth and their anti-inflammatory activity. Fitoterapia. 2014 Jul 10; 98C:84-90.
3.Shi HX, Yang J, Yang T, Xue YL, Liu J, Li YJ, Zhang DD, Xu JW, Bian K. Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II. Evid Based Complement Alternat Med. 2014; 2014:682041.
4.Chen CL, Zhang DD. Anti-Inflammatory Effects of 81 Chinese Herb Extracts and Their Correlation with the Characteristics of Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2014; 2014:985176.
5.Tan X, Wang YL, Yang XL, Zhang DD. Ethyl acetate extract of Artemisia anomala S. Moore displays potent anti-inflammatory effect. Evid Based Complement Alternat Med. 2014; 2014:681352.
6.Ling S, Xu JW. Model organisms and traditional Chinese medicine syndrome models. Evid Based Complement Alternat Med. 2013; 2013:761987.
7.Liangxing Tu, Yueneng Yi, Wei Wu, Fuqiang Hu, Kaili Hu*, Jianfang Feng. Effects of particle size on the pharmacokinetics of puerarin nanocrystals and microcrystals after oral administration to rat.International Journal of Pharmaceutics, 2013, 458(1): 135-140. (IF:3.785)
8.Han X, Ling S, Gan W, Sun L, Duan J, Xu JW. 2,3,5,4'-tetrahydroxystilbene -2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation. Atherosclerosis. 2012 Nov; 225(1):76-82.
9.Li PG, Sun L, Han X, Ling S, Gan WT, Xu JW. Quercetin induces rapid eNOS phosphorylation and vasodilation by an Akt-independent and PKA-dependent mechanism. Pharmacology. 2012; 89 (3-4):220-8.
10.Wang P, Sun L, Tan J, Xu JW, Guo F, Li Y. Two new glycosidated coumaramides from Clerodendron cyrtophyllum. Fitoterapia. 2012 Dec; 83(8):1494-9.
11.Kaili Hu, Shan Cao, Fuqiang Hu, Jianfang Feng. Enhanced oral bioavailability of docetaxel by lecithin nanoparticles: preparation, in vitro, and in vivo evaluation. Int J Nanomedicine, 2012, 7: 3537-3545. (IF:4.195)
12.Zhang L, Feng L, Jia Q, Xu JW, Wang R, Wang Z, Wu Y, Li Y. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Bioorg Med Chem. 2011 Aug 15; 19(16):4882-6.
13.DK, Tian, S Ling, G L Chen, YJ Li, J Liu, Murad Ferid, K Bian. Hypertensive nephropathy treatment by heart protecting musk pill: a study of anti-inflammatory therapy for target organ damage of hypertension. Int J Gen Med, 2011:4 131–139.
14.Kaili Hu, Yanbin Shi, Wenming Jiang, Jiaying Han, Shixian Huang, Xinguo Jiang. Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: preparation, characterization and efficacy in Parkinson's disease. International Journal of Pharmaceutics, 2011, 415(1-2): 273-283. (IF: 3.785)
15.Kaili Hu, Lin Zhu, Haiyuan Liang, Jianfang Feng. Improved antitumor efficacy and reduced toxicity of bufadienolides liposomes. Archives of Pharmacal Research, 2011, 34(9): 1487-1494. (IF: 1.751)
16.Xue YL, Shi HX, Murad F, Bian K. Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta. Vasc Health Risk Manag. 2011; 7:273-80.
17.Tian D, Ling S, Chen G, Li Y, Liu J, Ferid M, Bian K. Hypertensive nephropathy treatment by heart-protecting musk pill: a study of anti-inflammatory therapy for target organ damage of hypertension. Int J Gen Med. 2011 Feb 15; 4:131-9.
18.Li YJ, Bao JX, Xu JW, Murad F, Bian K. Vascular dilation by paeonol--a mechanism study. Vascul Pharmacol. 2010 Sep-Oct; 53(3-4):169-76.
19.Zhang T., Liu H., Liu X. T., Xu D. R., Chen X. Q., Wang Q. Qualitative and quantitative analysis of steroidal saponins in crude extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by high performance liquid chromatography coupled with mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2010, 51: 114-124
20.Zhang T., Liu H., Liu X. T., Chen X. Q., Wang Q. Steroidal saponins from the rhizomes of Paris delavayi. Steroids. 2009, 74: 809–813
21.Liu J, Cheng Gangling, Bian Ka. Prevention of CuZn-SOD self-nitration by total flavonoids from four traditional Chinese medicines. Prog Biochem Biophys, 2008，35（Suppl）356-257.
22.Sun L, Ke Y, Zhu CY, Tang N, Tian DK, Gao YH, Zheng JP, Bian K. Inflammatory reaction versus endogenous peroxisome proliferator-activated receptors expression, re-exploring secondary organ complications of spontaneously hypertensive rats. Chin Med J (Engl). 2008 Nov 20; 121(22):2305-11.
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