The Murad Research Center for Traditional Chinese Medicine Modernization

Release time:2015-01-09visits:(14)

Our mission

Established between the SHUTCM and Prof. Ferid Murad, a Noble laureate in Physiology or Medicine, the Center seeks to facilitate its modernization and internationalization of Chinese medicine through innovative basic and applied research.

Our research interests

lExtraction and discovery of active components

lSignalling of inflammatory cells

lAnti-cancer mechanism

lCardio-cerebrovascular pharmacology

lAnti-aging

lPreparation of Chinese materia medica

Our research projects

lBranch projects of National Basic Research Program of China (973 Program)

lNational Natural Science Foundation (General) Program

lNational Natural Science Foundation for Young Scholars

lProject of the State Administration of Traditional Chinese Medicine

lThe Rising-Star Program of Shanghai Science & Technology Commission

lSpecific Project for Modernization of Chinese Medicine

lSpecific Project of Nanotechnology

lInnovation Project of the Shanghai Education Commission

Our honors

lThe third prize of Shanghai Science & Technology Progress (2014)

lInternational SHR Association—Young Researcher Award (2012)

lAuthored two books: Molecular Targets of Drugs: Convergence and Divergence and Cutting-Edge Technology in Life Science and TCM Study

Our staff

Currently, the Center has 7 full-time researchers and 2 technicians.

Honorary Chairman: Prof. Ferid Murad

Director: Prof. Bian Ka

Deputy Director: Prof. Xu Jinwen


Bian Ka, Research focus: Anti-cancer and cardiovascular pharmacology

E-mail: kabian3@gmail.com

Xu Jinwen, Research focus: cardiovascular pharmacology from the molecular level and longevity medicine

E-mail: jwxu1001@163.com

Zhang Dandan, Research focus: Role of tumor-associated inflammation in breast cancer metastasis and discovery and mechanism in new Chinese medicine

E-mail: izhangdd@126.com

Zhang Ting, Research focus: Active components in Chinese materia medica and quality evaluation

E-mail: zhtcpu@163.com

Liu Jun, Research focus: Action mechanism of Chinese medicine for cancer and tumor stem cells

E-mail: junliu1995@163.com

Hu Kaili, Research focus: Construction of new delivery system of Chinese medicine and targeting preparation

E-mail: kaili-hu@163.com

Li Yajuan, Research focus: Cardiovascular pharmacology, inflammation medicine and Chinese medicine for diabetes

E-mail: lyj@shutcm.edu.cn

liyajuan9@sina.cn

Ling Shuang, Research focus: Cardio-cerebrovascular pharmacology and longevity pharmacology

E-mail: sarah_ling@126.com

Our achievements

2014

1.Zhu T, Zhang L, Ling S, Duan J, Qian F, Li Y, Xu JW. Scropolioside B inhibits IL-1ß and cytokines expression through NFκB and inflammasome NLRP3 pathways. Mediators of Inflammation. Accepted 20 August 2014.

2.Zhang L, Zhu T, Qian F, Xu JW, Dorje G, Zhao Z, Guo F, Li Y. Iridoid glycosides isolated from Scrophularia dentata Royle ex Benth and their anti-inflammatory activity. Fitoterapia. 2014 Jul 10; 98C:84-90.

3.Shi HX, Yang J, Yang T, Xue YL, Liu J, Li YJ, Zhang DD, Xu JW, Bian K. Alpha-Asarone Protects Endothelial Cells from Injury by Angiotensin II. Evid Based Complement Alternat Med. 2014; 2014:682041.

4.Chen CL, Zhang DD. Anti-Inflammatory Effects of 81 Chinese Herb Extracts and Their Correlation with the Characteristics of Traditional Chinese Medicine. Evid Based Complement Alternat Med. 2014; 2014:985176.

5.Tan X, Wang YL, Yang XL, Zhang DD. Ethyl acetate extract of Artemisia anomala S. Moore displays potent anti-inflammatory effect. Evid Based Complement Alternat Med. 2014; 2014:681352.

2013

6.Ling S, Xu JW. Model organisms and traditional Chinese medicine syndrome models. Evid Based Complement Alternat Med. 2013; 2013:761987.

7.Liangxing Tu, Yueneng Yi, Wei Wu, Fuqiang Hu, Kaili Hu*, Jianfang Feng. Effects of particle size on the pharmacokinetics of puerarin nanocrystals and microcrystals after oral administration to rat.International Journal of Pharmaceutics, 2013, 458(1): 135-140. (IF:3.785)

2012

8.Han X, Ling S, Gan W, Sun L, Duan J, Xu JW. 2,3,5,4'-tetrahydroxystilbene -2-O-β-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation. Atherosclerosis. 2012 Nov; 225(1):76-82.

9.Li PG, Sun L, Han X, Ling S, Gan WT, Xu JW. Quercetin induces rapid eNOS phosphorylation and vasodilation by an Akt-independent and PKA-dependent mechanism. Pharmacology. 2012; 89 (3-4):220-8.

10.Wang P, Sun L, Tan J, Xu JW, Guo F, Li Y. Two new glycosidated coumaramides from Clerodendron cyrtophyllum. Fitoterapia. 2012 Dec; 83(8):1494-9.

11.Kaili Hu, Shan Cao, Fuqiang Hu, Jianfang Feng. Enhanced oral bioavailability of docetaxel by lecithin nanoparticles: preparation, in vitro, and in vivo evaluation. Int J Nanomedicine, 2012, 7: 3537-3545. (IF:4.195)

2011

12.Zhang L, Feng L, Jia Q, Xu JW, Wang R, Wang Z, Wu Y, Li Y. Effects of β-glucosidase hydrolyzed products of harpagide and harpagoside on cyclooxygenase-2 (COX-2) in vitro. Bioorg Med Chem. 2011 Aug 15; 19(16):4882-6.

13.DK, Tian, S Ling, G L Chen, YJ Li, J Liu, Murad Ferid, K Bian. Hypertensive nephropathy treatment by heart protecting musk pill: a study of anti-inflammatory therapy for target organ damage of hypertension. Int J Gen Med, 2011:4 131–139.

14.Kaili Hu, Yanbin Shi, Wenming Jiang, Jiaying Han, Shixian Huang, Xinguo Jiang. Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: preparation, characterization and efficacy in Parkinson's disease. International Journal of Pharmaceutics, 2011, 415(1-2): 273-283. (IF: 3.785)

15.Kaili Hu, Lin Zhu, Haiyuan Liang, Jianfang Feng. Improved antitumor efficacy and reduced toxicity of bufadienolides liposomes. Archives of Pharmacal Research, 2011, 34(9): 1487-1494. (IF: 1.751)

16.Xue YL, Shi HX, Murad F, Bian K. Vasodilatory effects of cinnamaldehyde and its mechanism of action in the rat aorta. Vasc Health Risk Manag. 2011; 7:273-80.

17.Tian D, Ling S, Chen G, Li Y, Liu J, Ferid M, Bian K. Hypertensive nephropathy treatment by heart-protecting musk pill: a study of anti-inflammatory therapy for target organ damage of hypertension. Int J Gen Med. 2011 Feb 15; 4:131-9.

2010

18.Li YJ, Bao JX, Xu JW, Murad F, Bian K. Vascular dilation by paeonol--a mechanism study. Vascul Pharmacol. 2010 Sep-Oct; 53(3-4):169-76.

19.Zhang T., Liu H., Liu X. T., Xu D. R., Chen X. Q., Wang Q. Qualitative and quantitative analysis of steroidal saponins in crude extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by high performance liquid chromatography coupled with mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis. 2010, 51: 114-124

2009

20.Zhang T., Liu H., Liu X. T., Chen X. Q., Wang Q. Steroidal saponins from the rhizomes of Paris delavayi. Steroids. 2009, 74: 809–813

2008

21.Liu J, Cheng Gangling, Bian Ka. Prevention of CuZn-SOD self-nitration by total flavonoids from four traditional Chinese medicines. Prog Biochem Biophys, 200835Suppl356-257.

22.Sun L, Ke Y, Zhu CY, Tang N, Tian DK, Gao YH, Zheng JP, Bian K. Inflammatory reaction versus endogenous peroxisome proliferator-activated receptors expression, re-exploring secondary organ complications of spontaneously hypertensive rats. Chin Med J (Engl). 2008 Nov 20; 121(22):2305-11.

Contact Us

Address: Building No 2 (4th floor), 1200 Cailun Road, Pudong New Area, Shanghai 201203

Telephone: 021-51322532, 021-51322446, 021-51322535

Fax: 021-51323058